In all likelihood, there will be another pandemic! Most likely caused by a virus too. Readiness depends on a variety of factors that can be divided into four categories: worldwide, country level, local and personal. All are of utmost importance, but this presentation will emphasize the personal level of readiness. On the worldwide level stands the UN with the WHO. Surveillance of any potentially critical detection of threat is their responsibility, together with swift communication of vital information about specifics that can help initiate a global response. National disease monitoring institutions can also help here. On a national and local level, the readiness depends on the capacity and deployment of the health promotion and health care system in place. Readiness on a personal level involves all dimensions of wellness: physical (optimal nutrition, appropriate exercise, personal hygiene and physiotherapy), psychosocial, occupational and environmental. Vaccine hesitancy has been identified as a major threat to world health; it has played a major role in the current/past pandemic. Strategies to combat misinformation are needed in all four categories. Distrust in scientific investigation and information propagated by individuals and groups via social media is one of the main problems, while access to effective prevention and treatment is another. Reaching and maintaining a high level of wellness combined with an approach of caution on a personal level is the best prevention strategy, while home remedies, continued practice of health principles and know when to access the health care system is of vital importance when encountering the disease agent.